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OCR: lular In some GH-secreting adenomas, intrace ty are CAMP concentration and secretory activi ditions. In elevated, even under nonstimulated con le chain these tumours, oncogenic mutation in th alting genes of the Gs has been shown. The res e normal activation of adenylyl cyclase bypasses th GHRH andrequirement of the cell to be activated by es suggest is thus autonomous, Such exciting studi that we are beginning to understand the pathogenesis of pituitary tumours.